Finding key proteins that help repair DNA damage.
Identifying chromatin factors essential for DNA repair using a novel high-throughput screening methodology
This study is looking at how a special protein called ZNF280A helps fix DNA damage from things like UV rays, with the hope that understanding this process can lead to new treatments for age-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11059890 on NIH RePORTER |
What this research studies
This research investigates how certain proteins, specifically chromatin factors, play a crucial role in repairing DNA damage caused by environmental factors like UV radiation. Using a novel high-throughput screening method, researchers aim to identify these proteins and understand their function in the DNA damage response. The study focuses on a specific protein called ZNF280A and how it is regulated when DNA is damaged. By employing various scientific techniques, the research seeks to uncover fundamental mechanisms that could lead to new therapies for age-related diseases linked to DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for age-related diseases or those with a history of exposure to environmental toxins.
Not a fit: Patients with no history of DNA damage or those not affected by age-related pathologies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance DNA repair mechanisms, potentially reducing the risk of cancer and neurodegenerative diseases in patients.
How similar studies have performed: Previous research has shown promise in identifying chromatin factors involved in DNA repair, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Clarke, Thomas L — Boston University Medical Campus
- Study coordinator: Clarke, Thomas L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.