Finding immune and tissue signs that show when a therapeutic HIV vaccine works
Multi-Omics Correlates of Therapeutic Vaccine Efficacy
This project looks for patterns in immune cells and lymphoid tissues that could indicate when a therapeutic HIV vaccine helps people control the virus without daily antiretroviral therapy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11330341 on NIH RePORTER |
What this research studies
Researchers are analyzing existing samples from vaccinated SIV/SHIV-infected non-human primates to find immune and tissue changes linked to long-term viral control. They will use spatial multi-omics to combine gene, protein, and location information within lymphoid organs and other tissues. The team will compare animals that controlled the virus after combined immunizations with those that did not to identify protective immune signatures and reservoir reorganization. Findings are intended to guide the design of improved therapeutic vaccines for people living with HIV.
Who could benefit from this research
Good fit: People living with HIV who are interested in future therapeutic vaccine options or in joining vaccine clinical trials would be the eventual candidates informed by this work.
Not a fit: Because this is preclinical work using animal tissue samples, it will not provide direct treatment or immediate personal benefit to patients right now.
Why it matters
Potential benefit: Could reveal immune markers and tissue targets that lead to better therapeutic vaccines and ultimately help some people control HIV without daily ART.
How similar studies have performed: Therapeutic vaccine trials in humans have largely failed so far, but some non-human primate studies did produce a subset of animals with durable viral control, making this an exploratory but promising approach.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Juelg, Boris Dominik — Beth Israel Deaconess Medical Center
- Study coordinator: Juelg, Boris Dominik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.