Finding genetic markers for premenstrual dysphoric disorder (PMDD)
Identification and Validation of Epigenetic Biomarkers of PMDD
This study is looking at how certain genetic markers can help identify women with premenstrual dysphoric disorder (PMDD) by checking their hormone sensitivity during different times in their menstrual cycle, which could lead to better ways to diagnose and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11044260 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic biomarkers in identifying premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome characterized by significant mood disturbances. The study will assess women with and without PMDD during different phases of their menstrual cycles to determine if specific genetic markers can indicate sensitivity to hormonal changes. By using a repeated measures approach, the research aims to provide a more comprehensive understanding of how these biomarkers function across different hormonal environments. This could lead to improved diagnostic tools and treatment strategies for women suffering from PMDD.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with PMDD as well as healthy controls who do not have the disorder.
Not a fit: Patients who do not experience PMDD or related reproductive affective disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and targeted treatments for women with PMDD, improving their quality of life.
How similar studies have performed: Previous studies have shown success in identifying epigenetic biomarkers for postpartum depression, suggesting a promising avenue for similar research in PMDD.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Hantsoo, Liisa Victoria — Johns Hopkins University
- Study coordinator: Hantsoo, Liisa Victoria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.