Finding genetic markers for premenstrual dysphoric disorder (PMDD)
Official title: Identification and Validation of Epigenetic Biomarkers of PMDD
Funded at Johns Hopkins University · NIH-11044260 · Data updated 2026-11-12
This study is looking at how certain genetic markers can help identify women with premenstrual dysphoric disorder (PMDD) by checking their hormone sensitivity during different times in their menstrual cycle, which could lead to better ways to diagnose and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 20, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $641,263 |
| NIH project number | 1R01MH135896-01A1 |
| Project ID | NIH-11044260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with PMDD as well as healthy controls who do not have the disorder.
✕Less likely to help
Patients who do not experience PMDD or related reproductive affective disorders may not benefit from this research.
What this research studies
This research investigates the role of epigenetic biomarkers in identifying premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome characterized by significant mood disturbances. The study will assess women with and without PMDD during different phases of their menstrual cycles to determine if specific genetic markers can indicate sensitivity to hormonal changes. By using a repeated measures approach, the research aims to provide a more comprehensive understanding of how these biomarkers function across different hormonal environments. This could lead to improved diagnostic tools and treatment strategies for women suffering from PMDD.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and targeted treatments for women with PMDD, improving their quality of life.
How similar studies have gone: Previous studies have shown success in identifying epigenetic biomarkers for postpartum depression, suggesting a promising avenue for similar research in PMDD.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Hantsoo, Liisa Victoria — Johns Hopkins University
- Study coordinator: Hantsoo, Liisa Victoria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.