Finding genetic factors that influence tumors in Neurofibromatosis type 1
Official title: Identification of germline modifiers of Neurofibromatosis type 1 tumors
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10874120 · Data updated 2026-11-12
This study is looking at how certain genes might affect tumor growth in children with Neurofibromatosis type 1 (NF1), and it aims to help doctors understand the condition better and find more effective treatments for kids with NF1.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $656,513 |
| NIH project number | 1R01NS133200-01A1 |
| Project ID | NIH-10874120 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Neurofibromatosis type 1, particularly those with plexiform neurofibromas or optic pathway gliomas.
✕Less likely to help
Patients without a diagnosis of Neurofibromatosis type 1 or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that may influence the development and severity of tumors in children with Neurofibromatosis type 1 (NF1). By analyzing genetic variants in individuals with NF1, the team aims to identify specific genes that could affect tumor growth and burden. The study employs a multidisciplinary approach, utilizing genetic analysis, mouse models, and zebrafish models to explore these genetic influences. This research could lead to better risk assessment and targeted therapies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and personalized care for children with Neurofibromatosis type 1.
How similar studies have gone: Previous research has indicated that genetic modifiers play a role in other genetic disorders, suggesting potential success for this novel approach in NF1.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Ratner, Nancy — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Ratner, Nancy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.