Finding genetic factors that increase the risk of brain tumors in children
Official title: Identification and characterization of genetic risk factors in pediatric brain tumors
Funded at Children's Hosp of Philadelphia · NIH-10991674 · Data updated 2026-11-12
This study is looking at the genes that might cause brain tumors in kids and teens, so we can find better ways to predict and treat these tumors, helping young patients and their families.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $178,000 |
| NIH project number | 5R03CA287169-02 |
| Project ID | NIH-10991674 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with brain tumors and their family members who can provide genetic information.
✕Less likely to help
Patients with brain tumors who are older than 19 years may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to brain tumors in children aged 0-19 years. By analyzing both inherited and newly occurring genetic variants in tumor and germline DNA, the study aims to identify specific genetic markers that could help in predicting risk and developing targeted therapies. The research utilizes a large cohort of pediatric brain tumor patients and their families to gather comprehensive genetic data, which will be analyzed to understand the underlying causes of these tumors. The ultimate goal is to improve treatment outcomes for affected children through evidence-based approaches.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and more effective treatments for pediatric brain tumors.
How similar studies have gone: Previous research has shown promise in identifying genetic factors in pediatric cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Diskin, Sharon — Children's Hosp of Philadelphia
- Study coordinator: Diskin, Sharon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.