Finding Genetic Clues for Neurofibromatosis Type 1 Tumors
Identification of Germline Modifiers of Neurofibromatosis Type 1 Tumors
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11189768
This project aims to discover genetic factors that influence how tumors develop in people with Neurofibromatosis Type 1 (NF1).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11189768 on ClinicalTrials.gov |
What this research studies
Neurofibromatosis Type 1 (NF1) is a genetic condition that can lead to tumors like plexiform neurofibromas (PNF) and optic pathway gliomas (OPG). While the main NF1 gene is known, other genetic factors in a person's DNA, called germline modifiers, are believed to influence how severe the disease becomes. This project brings together a team of experts to identify these additional genetic factors. They will study genetic information from more individuals with NF1 and use mouse and zebrafish models to understand how these genes affect tumor growth. The ultimate goal is to better understand why some people with NF1 develop more severe tumors than others.
Who could benefit from this research
Good fit: Individuals with Neurofibromatosis Type 1 (NF1) who have plexiform neurofibromas (PNF) or optic pathway gliomas (OPG) are ideal candidates for this type of research.
Not a fit: Patients without Neurofibromatosis Type 1 or those whose tumors are not related to germline genetic modifiers may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help predict who is at higher risk for certain NF1 tumors and identify new ways to treat them.
How similar studies have performed: While twin studies suggest the existence of these genetic modifiers, their specific identification and role in NF1 tumor development are largely unexplored.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RATNER, NANCY — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: RATNER, NANCY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.