Finding genetic causes of repeated pregnancy loss
Large scale genome sequencing and integrative analyses to define genomic predictors of recurrent pregnancy loss
This project uses whole-genome sequencing of parents and pregnancy tissue to find genetic changes that may explain repeated miscarriages for people who have had multiple pregnancy losses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11228772 on NIH RePORTER |
What this research studies
If you and your partner have had multiple unexplained pregnancy losses, the team will enroll you and try to collect DNA from both parents and the pregnancy to form a trio. They will perform whole-genome sequencing and use advanced methods to detect rare coding, noncoding, and structural genetic changes that past studies often missed. The study also includes a small pilot RNA-sequencing effort to see if gene activity measurements help find causes. By combining detailed clinical information with these genomic data, researchers hope to map genes and chromosome regions needed for a successful pregnancy.
Who could benefit from this research
Good fit: People who have experienced multiple unexplained pregnancy losses and who can provide DNA from themselves, their partner, and the pregnancy tissue are the ideal candidates.
Not a fit: People whose pregnancy losses have a known non-genetic cause or already-identified chromosomal diagnosis, or those unable to provide pregnancy samples, may not benefit directly from this study.
Why it matters
Potential benefit: If successful, this work could provide clearer genetic explanations for recurrent pregnancy loss, improve counseling about future pregnancy risks, and point toward more personalized reproductive options.
How similar studies have performed: Previous smaller studies suggested genetic contributions to recurrent loss but were limited, and this large trio-based whole-genome approach is newer and more comprehensive.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Jiang, Yong-Hui — Yale University
- Study coordinator: Jiang, Yong-Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.