Finding genes whose activity is driven by genetics in Alzheimer's and related dementias
Identifying genetically driven gene dysregulation in Alzheimer's disease and related dementias using statistical data integration
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11241151
This project uses many types of brain molecular data to find genes that genetic risk may change in people with Alzheimer's and related dementias.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11241151 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, the research team will combine gene expression, protein, and epigenetic data from different brain regions and cell types to find genes whose activity is driven by genetic risk in Alzheimer's and related dementias. They will use statistical integration and a correlation-aware meta-analysis to merge imputed molecular profiles derived from postmortem brain tissue and single-nucleus datasets covering several dementia types. The goal is to pinpoint key genes and molecular pathways linked to disease risk and to share the results through an open online resource. This work is mainly computational and relies on existing human brain datasets rather than clinical visits.
Who could benefit from this research
Good fit: People with Alzheimer's disease, frontotemporal lobar degeneration, or dementia with Lewy bodies, and families willing to share medical data or brain tissue, would be most relevant to this work.
Not a fit: Patients seeking immediate treatment benefits or those without available medical records or tissue donations are unlikely to receive direct benefit from this computational project.
Why it matters
Potential benefit: If successful, this could reveal new gene targets and biological pathways that help guide development of better diagnostics or treatments for Alzheimer's and related dementias.
How similar studies have performed: Prior transcriptome- and proteome-wide studies have identified gene associations in Alzheimer's, but combining multiple molecular layers with a correlation-aware meta-analysis is a relatively new approach.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VOLOUDAKIS, GEORGIOS — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: VOLOUDAKIS, GEORGIOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's Disease and its related dementias