Finding genes linked to type 2 diabetes
Identifying Genes for Type 2 Diabetes: FUSION
Researchers will look for genetic differences that change the risk of type 2 diabetes in adults, including older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11392792 on NIH RePORTER |
What this research studies
This project compares DNA from large groups of people with and without type 2 diabetes to find gene changes tied to disease risk and related traits. Scientists use genetic arrays and DNA sequencing across cohorts from Finland, the United States, and diverse populations and combine the results in meta-analyses. People who carry specific high-interest genetic variants may be invited back for targeted clinical tests and physiological measurements, including studies of skeletal muscle using bulk and single-nucleus approaches, to learn how those genes affect metabolism. The team aims to link specific genetic changes to real body processes that could point to new treatments or better ways to predict risk.
Who could benefit from this research
Good fit: Ideal candidates are adults with or at risk for type 2 diabetes—especially those already enrolled in the FUSION, METSIM, or Michigan Genomics Initiative cohorts—who are willing to give blood and possibly return for additional tests or muscle sampling.
Not a fit: People seeking immediate treatment changes or urgent medical care should not expect direct health benefits from participation, and individuals unwilling to provide biological samples may not be eligible.
Why it matters
Potential benefit: If successful, this work could lead to improved risk tests, more precisely targeted therapies, and new drug targets for people with or at risk for type 2 diabetes.
How similar studies have performed: Large genome-wide studies have already identified many genes linked to type 2 diabetes, and this project builds on that work by adding deeper sequencing and muscle-level testing.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Boehnke, Michael L — University of Michigan at Ann Arbor
- Study coordinator: Boehnke, Michael L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.