Finding genes linked to type 2 diabetes
Identifying Genes for Type 2 Diabetes: FUSION
This project looks for genetic differences that change type 2 diabetes risk and related health measures in people, including older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11142477 on NIH RePORTER |
What this research studies
You would be part of research that compares DNA from large groups (including Finnish and U.S. cohorts) using genetic arrays and sequencing to find variants tied to type 2 diabetes. Researchers combine data across multiple cohorts and ancestries to pinpoint gene regions, then invite selected people with high-interest variants back for targeted testing and detailed health measurements. The team also studies skeletal muscle samples (bulk and single-nucleus) to learn how genetic changes affect body function. The overall aim is to turn genetic findings into better treatments, risk prediction, and lifestyle advice.
Who could benefit from this research
Good fit: Ideal candidates are adults willing to provide a DNA sample and clinical information, including people with type 2 diabetes or those at higher risk such as older adults.
Not a fit: People who cannot provide a DNA sample or clinical data, cannot attend follow-up testing, or whose diabetes is driven solely by non-genetic causes are unlikely to receive direct benefit.
Why it matters
Potential benefit: If successful, this work could point to new drug targets, improve prediction of who will develop diabetes, and help tailor treatments or prevention for individuals.
How similar studies have performed: Previous large genetic studies have identified many diabetes risk variants, and this project builds on those successes by using larger, more diverse cohorts and added muscle tissue analysis to find new mechanisms.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Boehnke, Michael L — University of Michigan at Ann Arbor
- Study coordinator: Boehnke, Michael L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.