Finding genes linked to nonsyndromic cleft lip and palate
Leveraging novel methods to improve nonsyndromic cleft lip/palate gene discovery
This study is looking at the genes that might cause nonsyndromic cleft lip and palate, a condition that affects some babies, by examining DNA from families of various backgrounds to help find ways to prevent and treat it better in the future.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10676885 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to nonsyndromic cleft lip and palate (NSCLP) by analyzing whole genome sequencing data from large families of different ethnic backgrounds. The study aims to identify both common and rare genetic variants that may increase the risk of NSCLP, which affects many newborns each year. By understanding these genetic contributions, the research seeks to unravel the complexities of this birth defect and improve future prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include newborns and children with nonsyndromic cleft lip and palate, particularly those from Hispanic and non-Hispanic white backgrounds.
Not a fit: Patients with syndromic forms of cleft lip and palate or those without any cleft lip/palate conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of nonsyndromic cleft lip and palate, potentially reducing its incidence and improving outcomes for affected individuals.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to cleft lip and palate, but this approach focuses on novel methods that may uncover previously hidden genetic risks.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Letra, Ariadne M — University of Pittsburgh at Pittsburgh
- Study coordinator: Letra, Ariadne M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.