Finding gene changes in individual leukemia cells for better diagnosis
Large scale single-cell gene rearrangement detection with a microfluidic device
This project is developing a new, more precise way to find genetic changes in individual leukemia cells to help doctors better understand and treat acute myeloid leukemia (AML).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project ID | NIH-11146427 on NIH RePORTER |
What this research studies
Acute myeloid leukemia (AML) is a serious cancer, and current ways to diagnose it and choose treatments aren't always as precise as we need. This project is creating a new method called S-CytoSeq, which uses advanced technology to look at the genetic makeup of individual leukemia cells. By examining many cells one by one, S-CytoSeq can find specific gene changes, like fusion genes and alternative splicing, with much greater detail. The hope is that this new approach will give doctors a clearer picture of a patient's AML, leading to more effective and personalized treatment plans.
Who could benefit from this research
Good fit: Patients with acute myeloid leukemia could potentially benefit from the improved diagnostic and treatment selection capabilities developed through this work.
Not a fit: Patients without acute myeloid leukemia would not directly benefit from this specific diagnostic improvement.
Why it matters
Potential benefit: If successful, this new method could lead to more accurate diagnoses and better-tailored treatment choices for patients with acute myeloid leukemia.
How similar studies have performed: This project builds upon existing single-cell analysis technologies, applying them in a novel way to improve AML diagnostics.
Where this research is happening
Loma Linda, UNITED STATES
- Loma Linda University — Loma Linda, United States (Active)
Researchers
- Principal investigator: Zhong, John — Loma Linda University
- Study coordinator: Zhong, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.