Finding early signs of Post-Treatment Lyme Disease Syndrome
Discovery of early immunologic biomarkers for risk of PTLDS through machine learning-assisted broad temporal profiling of humoral immune response
This project looks for early warning signs in your immune system that might tell us if you are at risk for developing long-term symptoms after Lyme disease treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11124731 on NIH RePORTER |
What this research studies
Many people with Lyme disease get better with antibiotics, but some develop long-lasting symptoms like fatigue and joint pain, known as Post-Treatment Lyme Disease Syndrome (PTLDS). Currently, there isn't a good way to predict who will get PTLDS, which makes it hard for doctors to offer early help. This work uses advanced computer methods to study immune responses in people with acute Lyme disease. The goal is to find specific markers that can tell us early on if someone is likely to develop PTLDS, opening the door for earlier and more effective care.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals recently diagnosed with acute Lyme disease.
Not a fit: Patients who do not have Lyme disease or who have already developed established PTLDS may not directly benefit from this early risk assessment.
Why it matters
Potential benefit: If successful, this work could allow doctors to identify patients at risk for PTLDS early, potentially leading to interventions that improve long-term health outcomes.
How similar studies have performed: While this specific biomarker discovery for PTLDS is novel, the concept of early intervention based on risk assessment has shown promise in other chronic and autoimmune conditions.
Where this research is happening
Scottsdale, United States
- Arizona State University-Tempe Campus — Scottsdale, United States (Active)
Researchers
- Principal investigator: Woodbury, Neal Walter — Arizona State University-Tempe Campus
- Study coordinator: Woodbury, Neal Walter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.