Finding early signs of Alzheimer's disease using special probes
Official title: Identifying biomarkers for the early detection of Alzheimer's disease using phage display
Funded at University of West Florida · NIH-10974577 · Data updated 2026-11-12
This study is working on a new blood or spinal fluid test to spot early signs of Alzheimer's disease by looking for specific changes in a protein called tau, which could help doctors diagnose and track the disease better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of West Florida NIH-funded |
| Lab location | 1 site (Pensacola, United States) |
| Project start | March 1, 2020 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $421,500 |
| NIH project number | 2R15AG066122-02 |
| Project ID | NIH-10974577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease or those experiencing early symptoms of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive symptoms may not benefit from this research.
What this research studies
This research aims to develop a new screening test that can detect early biochemical changes related to Alzheimer's disease (AD) by analyzing blood or cerebrospinal fluid (CSF). The focus is on identifying specific protein modifications associated with AD, particularly those related to the tau protein. By using phage display technology, the researchers hope to create highly sensitive probes that can accurately identify these changes, leading to better diagnosis and monitoring of the disease. The study will validate its findings in a larger group of participants to ensure its effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, allowing for timely interventions.
How similar studies have gone: Previous research has shown promise in using similar biomarker approaches for Alzheimer's detection, indicating potential for success in this study.
Where this research is happening
-
University of West Florida
Pensacola, United States Active
Researchers
- Principal investigator: Guttmann, Rodney P — University of West Florida
- Study coordinator: Guttmann, Rodney P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.