Finding early heart changes after preeclampsia with exercise testing
Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing
This project uses exercise heart tests and blood/echo measures to find early signs of a heart-failure type called HFpEF in women who had preeclampsia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11171578 on NIH RePORTER |
What this research studies
If you've had preeclampsia, this project will invite you to come in for exercise stress tests, heart ultrasounds, blood biomarker tests, and special hemodynamic measurements. The team will compare heart function, structure, exercise capacity, and blood proteins between women with and without prior preeclampsia to identify patterns linked to early HFpEF. They plan to enroll diverse women and use exercise-based hemodynamic challenges to reveal subtle problems that resting tests may miss. Results will be used to define a risk profile that could guide future targeted prevention or treatments.
Who could benefit from this research
Good fit: Ideal candidates are adult women (21+) with a history of preeclampsia who can travel to the study site and are willing to undergo exercise testing, echocardiography, and blood draws.
Not a fit: People without a history of preeclampsia, men, or those with established symptomatic heart failure are unlikely to benefit directly from this study.
Why it matters
Potential benefit: If successful, this work could allow earlier detection and targeted prevention of HFpEF in women who had preeclampsia.
How similar studies have performed: Prior research links preeclampsia to later HFpEF risk, but this large, exercise-based hemodynamic and biomarker approach to defining early HFpEF is largely novel.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Lindley, Kathryn — Vanderbilt University Medical Center
- Study coordinator: Lindley, Kathryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.