Finding early brain signs of psychosis in adolescents and young people
Discovering prognostic neuroimaging biomarkers of the psychosis spectrum using network control theory
This work uses brain scans and computer models to find early brain patterns that could signal future psychosis in adolescents and young adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11141673 on NIH RePORTER |
What this research studies
You would be part of research that analyzes large collections of brain scans taken over time from adolescents and young adults to spot patterns that appear before psychosis symptoms. Scientists will apply network neuroscience and machine learning to map how different brain regions communicate and how those connections change during development. The project combines multiple existing longitudinal and cross-sectional neuroimaging datasets and examines sex differences in development. The aim is to find brain markers that might flag higher risk years before full symptoms develop.
Who could benefit from this research
Good fit: Ideal candidates are adolescents and young adults who are at clinical high risk for psychosis or have early, emerging psychosis and who can contribute to longitudinal imaging or clinical data.
Not a fit: People without any risk for psychosis or older adults with long-standing schizophrenia are unlikely to benefit directly from these early-development biomarkers.
Why it matters
Potential benefit: If successful, this could help identify young people at higher risk for psychosis earlier so they can get closer monitoring or preventive care.
How similar studies have performed: Previous imaging and machine-learning work has identified risk-related brain differences, but combining network control theory with large longitudinal datasets is a relatively new and less-tested approach.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Parkes, Linden — Rutgers Biomedical and Health Sciences
- Study coordinator: Parkes, Linden
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.