Finding drugs to reduce brain inflammation for Alzheimer's disease treatment
Discovery of Drugs that Modulate Neuroinflammation for the treatment of Alzheimer's Disease
This study is looking for new medications that might help reduce brain inflammation and improve symptoms like memory loss and anxiety in people with Alzheimer's disease, using tests in mice to find the best and safest options for future treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10863958 on NIH RePORTER |
What this research studies
This research focuses on discovering new drugs that can help reduce neuroinflammation, which is believed to play a significant role in the progression of Alzheimer's disease. The team is investigating a promising compound that interacts with specific brain receptors to potentially alleviate cognitive deficits, anxiety, and aggressive behavior associated with Alzheimer's. By conducting in vivo studies in mouse models, they aim to optimize the drug's effectiveness and safety. If successful, this research could lead to new treatment options for patients suffering from Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with Alzheimer's disease who may experience cognitive deficits, anxiety, or aggressive behavior.
Not a fit: Patients with early-stage Alzheimer's or those not exhibiting significant neuroinflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options that may slow the progression of Alzheimer's disease and improve quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting neuroinflammation for Alzheimer's treatment, suggesting that this approach could be a viable avenue for new therapies.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hodgetts, Kevin — Brigham and Women's Hospital
- Study coordinator: Hodgetts, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.