Finding drugs that help people with Alzheimer's disease stay mentally strong
Official title: Identify actionable drugs that enhance resilience in Alzheimer's disease individuals
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11142599 · Data updated 2026-11-12
This study is looking for medications that can help people with Alzheimer's disease keep their thinking skills strong, using smart technology to understand how certain genes and biological processes work together.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $195,000 |
| NIH project number | 5R21AG087299-02 |
| Project ID | NIH-11142599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who exhibit cognitive resilience despite their condition.
✕Less likely to help
Patients with advanced Alzheimer's disease who have significant cognitive decline may not benefit from this research.
What this research studies
This research aims to identify drugs that can enhance cognitive resilience in individuals with Alzheimer's disease. By using advanced techniques like perturbation screening and artificial intelligence, the study will explore how certain genes and biological pathways contribute to maintaining cognitive function despite the presence of Alzheimer's-related conditions. The approach involves high-throughput profiling and computational modeling to uncover the interactions between various biological factors. Ultimately, the goal is to find actionable treatments that can help patients maintain their cognitive abilities.
Why it matters
Potential benefit: If successful, this research could lead to new drug therapies that help individuals with Alzheimer's disease preserve their cognitive function.
How similar studies have gone: Other research has shown promise in identifying resilience factors in neurological disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Dai, Yulin — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Dai, Yulin
Related research
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Why some brains resist or cope with Alzheimer's
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.