Finding clinically useful molecular subtypes for breast cancer and childhood asthma
Disease subtyping guided by clinical phenotype for precision medicine
Researchers are creating new methods that combine molecular test results with clinical information to identify patient groups that could guide treatment for breast cancer and childhood asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11240275 on NIH RePORTER |
What this research studies
If you have breast cancer or childhood asthma, this project develops "outcome-guided clustering" methods that combine your molecular test results with clinical outcomes and biological pathway knowledge. The team will build approaches for single-omics data and for integrating multiple omics datasets, then apply and validate them using existing patient data. The methods aim to find patient subgroups that relate to prognosis or likely treatment response. Those subgroup labels could help match patients to more precise treatments or guide future clinical trials.
Who could benefit from this research
Good fit: Ideal candidates are people whose medical records and molecular test results are available—particularly patients with breast cancer or children with asthma included in the study datasets.
Not a fit: Patients without breast cancer or asthma, or those seeking an immediate new therapy rather than data-driven subgrouping, are unlikely to receive direct benefit from this methods-focused work.
Why it matters
Potential benefit: If successful, this could help identify subgroups of patients who may benefit from more personalized treatment choices or targeted research.
How similar studies have performed: Unsupervised molecular clustering has previously found useful subtypes in diseases like breast cancer, but outcome-guided and multi-omics integration approaches are newer and show promising but still emerging results.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Tseng, George C. — University of Pittsburgh at Pittsburgh
- Study coordinator: Tseng, George C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.