Finding blood markers and causes of alcohol-related acute pancreatitis
Official title: Biomarkers and pathogenesis of Alcoholic acute pancreatitis
Funded at Mayo Clinic Arizona · NIH-11243487 · Data updated 2026-11-12
This project looks for blood markers that could help doctors identify when pancreatitis is caused by alcohol and predict how severe it will be for people admitted with acute pancreatitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | March 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $553,010 |
| NIH project number | 5R01AA031257-03 |
| Project ID | NIH-11243487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults hospitalized with acute pancreatitis, especially when alcohol may be the cause, who can provide blood samples and medical history are the ideal candidates.
✕Less likely to help
People whose pancreatitis is clearly due to non-alcohol causes or who cannot provide blood samples or clinical information may not benefit directly from this project.
What this research studies
If you join, researchers will collect blood samples from people hospitalized with acute pancreatitis to measure chemicals called FAEEs and PEth. They will compare marker levels in people thought to have alcohol-related pancreatitis versus other causes and will relate levels to how sick people become. The team will also look at how fat breakdown in the belly might release FAEEs that make the illness worse. Results come from patient samples and clinical records at the hospital.
Why it matters
Potential benefit: If successful, this work could let doctors more reliably detect alcohol-related pancreatitis and identify patients at risk for severe illness sooner.
How similar studies have gone: Prior smaller studies and laboratory data suggest FAEEs and PEth are promising markers for alcohol-related pancreatitis, but they have not yet been validated in larger clinical studies.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Singh, Vijay Prem — Mayo Clinic Arizona
- Study coordinator: Singh, Vijay Prem
Related research
Other NIH-funded projects on the same topics.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
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Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
-
Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
-
Epidemiology and causes of diabetes after acute pancreatitis
A long-term study following people who have had acute pancreatitis to understand how often diabetes develops, why it happens, and how it progresses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.