Finding bladder cancer early using urine samples
Early detection of bladder cancer through urothelial cell enrichment and DNA flow cytometry
['FUNDING_CAREER'] · JOHNS HOPKINS UNIVERSITY · NIH-11109419
This work aims to develop a new, easier urine test to find bladder cancer sooner, especially for people who might have blood in their urine.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11109419 on ClinicalTrials.gov |
What this research studies
Bladder cancer is a common and costly disease, and current screening methods can be uncomfortable or not very accurate. This project builds on previous work that used DNA from urine to detect bladder cancer without invasive procedures. The goal is to improve this urine test by making it more accurate, especially when blood is present, and less expensive. Researchers are working on a new technique to collect specific cells from urine and then use a simpler DNA analysis method to look for signs of cancer.
Who could benefit from this research
Good fit: This research is relevant for individuals at risk for bladder cancer, particularly those who experience blood in their urine.
Not a fit: Patients who have already been diagnosed with bladder cancer or are not at risk for the disease may not directly benefit from this early detection method.
Why it matters
Potential benefit: If successful, this could lead to a highly accurate, non-invasive, and affordable urine test for early bladder cancer detection, potentially improving treatment outcomes.
How similar studies have performed: Previous work by this team has shown promising results using urinary DNA for noninvasive bladder cancer detection, and this project aims to overcome current limitations.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUDLEY, JONATHAN CARL — JOHNS HOPKINS UNIVERSITY
- Study coordinator: DUDLEY, JONATHAN CARL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.