Finding biomarkers to predict outcomes in children with Multisystem Inflammatory Syndrome related to COVID-19
Official title: Identifying biomarker signatures of prognostic value for Multisystem Inflammatory Syndrome in Children (MIS-C)
Funded at Connecticut Children's Medical Center · NIH-10847825 · Data updated 2026-11-12
This study is looking at how certain biological markers in kids and young adults can help doctors understand the risk of serious complications from Multisystem Inflammatory Syndrome (MIS-C) after COVID-19, so they can make better treatment choices.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Connecticut Children's Medical Center NIH-funded |
| Lab location | 1 site (Hartford, United States) |
| Project start | January 1, 2021 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,558,561 |
| NIH project number | 3R33HD105613-03S1 |
| Project ID | NIH-10847825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults under 21 years old who have been diagnosed with COVID-19, particularly those exhibiting symptoms of MIS-C.
✕Less likely to help
Patients who are over 21 years old or those who have not been infected with COVID-19 are unlikely to benefit from this research.
What this research studies
This research investigates how certain biological markers can help predict the severity of Multisystem Inflammatory Syndrome in Children (MIS-C) that may arise after COVID-19 infection. By analyzing samples from children and young adults with varying degrees of COVID-19 severity, the study aims to identify specific biomarkers that indicate a higher risk of severe complications. The approach includes advanced techniques like Grating-Coupled Fluorescence Plasmonic (GCFP) and flow cytometry to gather detailed immunological and molecular data. This information could ultimately guide treatment decisions and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and targeted treatments for children at risk of severe complications from COVID-19.
How similar studies have gone: Other research has shown promise in identifying biomarkers for various conditions, suggesting that this approach could yield valuable insights for MIS-C as well.
Where this research is happening
-
Connecticut Children's Medical Center
Hartford, United States Active
Researchers
- Principal investigator: Salazar, Juan C — Connecticut Children's Medical Center
- Study coordinator: Salazar, Juan C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.