Finding biomarkers to improve treatment for chronic eye pain after cataract surgery
Official title: Identifying multimodal biomarkers for autologous serum tears in the treatment of chronic postoperative ocular pain
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10794761 · Data updated 2026-11-12
This study is looking to find out which patients with ongoing eye pain after cataract surgery will benefit from a special eye drop treatment made from their own serum, using smart technology to analyze their health information.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 20, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,557,093 |
| NIH project number | 1UG3NS131785-01A1 |
| Project ID | NIH-10794761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 55 and older who have undergone cataract surgery and are experiencing chronic postoperative ocular pain.
✕Less likely to help
Patients who have not had cataract surgery or those without chronic ocular pain may not benefit from this research.
What this research studies
This research aims to identify specific biological markers that can predict how well patients will respond to autologous serum tears (AST) for treating chronic postoperative ocular pain (CPOP) following cataract surgery. By utilizing advanced machine learning techniques, the study will analyze various clinical histories and biological data to determine which patients are likely to benefit from AST therapy. The interdisciplinary team includes experts in ophthalmology, pain management, and molecular biology, ensuring a comprehensive approach to understanding and addressing this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients suffering from chronic eye pain after cataract surgery.
How similar studies have gone: Previous research has shown promise in using biomarkers for predicting treatment responses in various medical conditions, suggesting potential success for this novel approach.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Sayegh, Rony Roger — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Sayegh, Rony Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.