Finding better ways to identify and understand frontotemporal lobar degeneration (FTLD)
Pathology-guided biofluid biomarker strategies for classification and progression of frontotemporal lobar degeneration (FTLD)
This research aims to discover new ways to classify and track frontotemporal lobar degeneration (FTLD) by studying markers in blood and spinal fluid.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11195601 on NIH RePORTER |
What this research studies
Frontotemporal lobar degeneration (FTLD) is a group of brain diseases that currently have no cure or way to slow their progression, and it's often hard to tell the exact type of FTLD a person has. This makes it difficult to develop and test new treatments. Our team is looking at samples of spinal fluid and blood from people with FTLD, including those with specific genetic forms, to find unique markers. We hope to create new tools that can accurately identify different types of FTLD and predict how the disease might progress, which could greatly help future clinical trials and patient care.
Who could benefit from this research
Good fit: This research is relevant for individuals diagnosed with frontotemporal lobar degeneration (FTLD), Alzheimer's disease, or those who are healthy controls.
Not a fit: Patients with conditions unrelated to neurodegenerative diseases like FTLD or Alzheimer's would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more accurate diagnosis and better ways to monitor FTLD, paving the way for new treatments.
How similar studies have performed: Current biomarkers for FTLD are limited, making this a novel approach to develop much-needed tools for classification and prognosis.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Cousins, Katheryn Alexandra Quilico — University of Pennsylvania
- Study coordinator: Cousins, Katheryn Alexandra Quilico
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.