Finding better ways to diagnose tuberculosis in young children in Malawi.

Who could benefit from this research

What this research studies

This research focuses on developing non-invasive diagnostic methods for tuberculosis (TB) in children under five years old in Malawi, particularly those suffering from severe acute malnutrition. The project aims to understand how malnutrition affects the treatment of TB and to improve detection strategies that can be implemented in low-resource settings. By combining mentorship and practical experiences, the research will enhance the candidate's ability to lead clinical studies that address these critical health issues in children.

Why it matters

Where this research is happening

• Henry Ford Health + Michigan State University Health Sciences
  East Lansing, United States Active

Researchers

• Principal investigator: Vonasek, Bryan — Henry Ford Health + Michigan State University Health Sciences
• Study coordinator: Vonasek, Bryan

Related research

Other NIH-funded projects on the same topics.

• Urine color test to check tuberculosis drug levels in children and adults

  This project uses a simple urine color test to see whether children and adults with TB are getting enough of key TB medicines like rifampin.

  NIH research University of Virginia · Charlottesville, United States · NIH-11468977

• Treatment options for isoniazid-resistant TB: safety, effectiveness, and drug levels with a standard regimen

  This grant studies whether a standard TB treatment plan that includes levofloxacin is safe and effective for people with isoniazid-resistant TB in Peru.

  NIH research Socios En Salud Sucursal Peru · Lima, Peru · NIH-11421427

• How lung cavities and granulomas affect TB inflammation and drug levels

  This project looks at how damaged lung areas in people with pulmonary tuberculosis influence inflammation and whether antibiotics reach those spots.

  NIH research Emory University · Atlanta, United States · NIH-11285240

• Urine color test to monitor TB medicine levels in children and adults

  This project uses a simple urine color measurement to check how well TB medicines, especially rifampin, reach the body in children and adults.

  NIH research University of Virginia · Charlottesville, United States · NIH-11250115

• Evaluating a new treatment for antibiotic-resistant tuberculosis

  This study is looking at a new treatment for antibiotic-resistant tuberculosis to see how well it works and how safe it is for patients, so we can find better options for people dealing with this tough infection.

  NIH research Icon Government and Public Health Solutions, INC. · Hinckley, United States · NIH-11166262

• Improving treatment for isoniazid-resistant tuberculosis

  This project tests whether replacing isoniazid with levofloxacin and adjusting doses gives safer, more effective treatment for adults with isoniazid-resistant TB.

  NIH research Socios En Salud Sucursal Peru · Lima, Peru · NIH-11120877

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.