Finding better ways to diagnose and treat a specific type of kidney injury
Biomarkers for acute interstitial nephritis in humans
This project aims to find new ways to diagnose a serious kidney injury called acute interstitial nephritis and help doctors know which treatments will work best for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11098638 on NIH RePORTER |
What this research studies
Acute interstitial nephritis (AIN) is a kidney injury often caused by medications or autoimmune diseases, leading to permanent kidney damage in many patients. Currently, diagnosing AIN requires a kidney biopsy, which can be risky or delayed, impacting recovery. The standard treatment, corticosteroids, doesn't help everyone, and we don't know who will respond well. This work seeks to identify specific markers in urine that can diagnose AIN without a biopsy and help predict which patients will benefit most from corticosteroid therapy.
Who could benefit from this research
Good fit: Patients who have or are suspected of having acute interstitial nephritis, especially those aged 21 and older, would be ideal candidates for this type of research.
Not a fit: Patients without acute interstitial nephritis or those whose kidney issues stem from other causes would likely not benefit directly from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier, less invasive diagnosis of AIN and more personalized, effective treatment plans, potentially preventing permanent kidney damage.
How similar studies have performed: Previous work by the researchers at Yale-affiliated hospitals has shown promising initial results for these urine markers in a group of 265 patients.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Moledina, Dennis G. — Yale University
- Study coordinator: Moledina, Dennis G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.