Finding and removing HIV-1 from brain cells
HIV-1DetectionandEliminationFrom CNS Mononuclear Phagocytes
This research looks for ways to find and get rid of the HIV-1 virus that hides in certain brain cells of people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11131195 on NIH RePORTER |
What this research studies
Even with effective HIV medication, the virus can sometimes hide in specific brain cells, acting as a 'reservoir' that makes it hard to completely clear the infection. This hidden virus can contribute to health issues for people living with HIV. Our goal is to better understand how HIV enters the brain and infects these particular cells, and to learn more about the size and nature of these hidden virus pockets. By gaining this knowledge, we hope to develop new strategies to detect and eliminate the virus from these brain reservoirs, moving closer to a cure.
Who could benefit from this research
Good fit: This research focuses on understanding HIV in the brain of people living with HIV who are currently receiving antiretroviral therapy.
Not a fit: Patients who do not have HIV or are not on antiretroviral therapy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that completely remove HIV from the brain, improving long-term health for people living with HIV.
How similar studies have performed: While the concept of HIV reservoirs is known, this specific approach aims to fill gaps in understanding the brain's viral reservoirs, suggesting a novel focus.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Gorantla, Santhi — University of Nebraska Medical Center
- Study coordinator: Gorantla, Santhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.