Finding a way to silence hidden HIV viruses in the body.
Sustained HIV Remission via Sequence-Specific Epigenetic Silencing of Latent Proviruses
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10792859
This study is exploring a new way to help people with HIV by finding a method to turn off hidden viruses in the body, so they can stop taking daily medication and enjoy a better quality of life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10792859 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a method to achieve long-term remission of HIV by targeting and silencing latent HIV proviruses that remain in the body despite treatment. The approach aims to use a technique called epigenetic silencing, which would permanently inactivate these hidden viruses without the need for ongoing antiretroviral therapy. By inducing a deeper state of latency in these viruses, the goal is to eliminate the need for daily medication and reduce the associated toxicities and logistical challenges of treatment. This innovative strategy could potentially provide a functional cure for HIV, improving the quality of life for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV who are currently on antiretroviral therapy but still harbor latent viruses.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a functional cure for HIV, allowing patients to live without the need for daily antiretroviral therapy.
How similar studies have performed: While there have been various approaches to HIV treatment, this specific method of sequence-specific epigenetic silencing is novel and has not been extensively tested in clinical settings.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROMERIO, FABIO — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ROMERIO, FABIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.