Finding a way to detect a specific genetic marker in pediatric lung cancer
Detecting DICER1: A global partnership to cure pediatric lung cancer
This study is looking at a special gene called DICER1 to help create a blood test that can find signs of lung cancer in kids, called pleuropulmonary blastoma, so doctors can better decide who needs treatment and who might not, all to help improve care for these young patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospitals and Clinics NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11034103 on NIH RePORTER |
What this research studies
This research investigates pleuropulmonary blastoma (PPB), the most common lung cancer in children, particularly focusing on the role of the DICER1 gene. The study aims to develop a blood-based test called DICER-Dx to identify circulating tumor DNA, which could help in monitoring the disease and determining the need for chemotherapy. By analyzing the genetic variations associated with DICER1, the research seeks to improve risk stratification for children diagnosed with PPB, ensuring that those who need more intensive treatment receive it while sparing others from unnecessary side effects. The project is part of a larger international effort to enhance outcomes for children with this rare cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 7 years old who have been diagnosed with pleuropulmonary blastoma.
Not a fit: Patients diagnosed with other types of lung cancer or those over the age of 7 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate monitoring and treatment decisions for children with pleuropulmonary blastoma, potentially improving survival rates and reducing treatment-related side effects.
How similar studies have performed: Previous research has shown promise in using blood-based assays for tumor monitoring in various cancers, suggesting that this approach may be effective for pleuropulmonary blastoma as well.
Where this research is happening
Minneapolis, United States
- Children's Hospitals and Clinics — Minneapolis, United States (Active)
Researchers
- Principal investigator: Schultz, Kris Ann Pinekenstein — Children's Hospitals and Clinics
- Study coordinator: Schultz, Kris Ann Pinekenstein
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.