Finding a new treatment target for pain caused by endometriosis
Identification of a Novel Target for the Treatment of Endometriosis-associated Pain
['FUNDING_R21'] · BOSTON CHILDREN'S HOSPITAL · NIH-10705085
This study is exploring a new way to help people with endometriosis pain by looking at how a special substance called protectin DX can ease pain and reduce growths, which could lead to better treatments for those affected.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10705085 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to treat endometriosis-associated pain by identifying the receptor for a specific lipid mediator called protectin DX (PDX). Using a validated mouse model of endometriosis pain, the researchers aim to understand how PDX alleviates pain and reduces lesions. They will employ advanced techniques to identify the G-protein coupled receptor (GPCR) that PDX interacts with, which could lead to the development of new therapeutic options for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of childbearing age who experience chronic abdominal or pelvic pain due to endometriosis.
Not a fit: Patients who do not have endometriosis or those whose pain is not related to this condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively alleviate pain for women suffering from endometriosis.
How similar studies have performed: Previous research has shown promise in targeting GPCRs for pain management, indicating that this approach could be effective.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROGERS, MICHAEL SEAN — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: ROGERS, MICHAEL SEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.