Finding a cure for kidney inflammation caused by lupus
Targeting Aberrant Expression of Cytokines/Chemokines for an Inflammatory Nephritis Cure
This study is looking at how a protein called MG53 might help reduce inflammation and protect the kidneys in people with lupus nephritis, and it aims to find new ways to improve kidney health for those affected by this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10651843 on NIH RePORTER |
What this research studies
This research focuses on lupus nephritis, a serious kidney condition linked to autoimmune disease. It aims to understand how certain proteins, particularly MG53, can help reduce inflammation and prevent kidney damage. By studying mouse models and using advanced techniques like microscopy and molecular studies, the researchers hope to discover new ways to manage and treat this condition effectively. The goal is to manipulate levels of MG53 to improve kidney health in patients suffering from lupus nephritis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lupus nephritis or systemic lupus erythematosus.
Not a fit: Patients without lupus or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve kidney function and quality of life for patients with lupus nephritis.
How similar studies have performed: Previous research has shown promise in targeting inflammatory mediators for autoimmune conditions, suggesting potential success for this approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Lin, Pei-Hui — Ohio State University
- Study coordinator: Lin, Pei-Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.