Fibroblasts influence prostate growth and development
Interstitial fibroblasts drive prostate branching morphogenesis
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11044181
This study is looking at how certain cells around the prostate help it grow and change, especially in men with benign prostatic hyperplasia (BPH), to find out more about what causes prostate issues and how they might develop.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11044181 on ClinicalTrials.gov |
What this research studies
This research investigates how interstitial fibroblasts, a type of cell surrounding the prostate, contribute to the growth and branching of prostate tissue. By analyzing these cells in both normal and diseased states, particularly benign prostatic hyperplasia (BPH), the researchers aim to uncover the signaling mechanisms that drive prostate development. The study employs advanced techniques like spatial transcriptomics to understand the interactions between these fibroblasts and prostate epithelial cells. This could lead to new insights into how prostate conditions develop and progress.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult males experiencing symptoms of benign prostatic hyperplasia or those interested in prostate health.
Not a fit: Patients with prostate cancer or other severe prostate conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for benign prostatic hyperplasia and improve understanding of prostate health.
How similar studies have performed: Previous research has shown promising results in understanding the role of fibroblasts in other tissues, suggesting potential for success in this area as well.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STRAND, DOUGLAS WILLIAM — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: STRAND, DOUGLAS WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.