Fibroblast laminin and repair of the brain's blood barrier after bleeding
Fibroblast-derived laminin regulates blood-brain barrier integrity and fibroblast biology in hemorrhagic brain
Testing whether a protein made by scar-forming cells (fibroblasts) helps rebuild the blood–brain barrier after intracerebral hemorrhage to limit brain damage and aid recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11160566 on NIH RePORTER |
What this research studies
This project uses mouse models of intracerebral hemorrhage and lab-grown human cells to study how laminin produced by fibroblasts affects blood–brain barrier repair and scar formation after brain bleeding. Researchers will compare mice that lack fibroblast laminin to normal mice to see how its absence changes leakage, immune cell entry, and tissue injury. In lab experiments they will test how laminin interacts with blood vessel cells, using drugs and genetic tools to find the receptors that mediate protective effects. They will also examine how laminin affects fibroblast growth, movement, and the composition of fibrotic scars.
Who could benefit from this research
Good fit: People who recently experienced an intracerebral hemorrhage (brain bleed) and their caregivers are the most relevant candidates for future therapies informed by this work.
Not a fit: People with non-hemorrhagic strokes, chronic neurodegenerative conditions unrelated to blood–brain barrier damage, or late-stage irreversible brain injury are less likely to benefit.
Why it matters
Potential benefit: If successful, this work could point to new treatments that protect or restore the blood–brain barrier after brain bleeds, reducing damage and improving recovery.
How similar studies have performed: Prior animal studies of extracellular matrix proteins have suggested ways to protect the blood–brain barrier, but the specific role of fibroblast-derived laminin in intracerebral hemorrhage is largely novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yao, Yao — University of South Florida
- Study coordinator: Yao, Yao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.