Fibrinogen and Alzheimer's
Role of Fibrinogen in Alzheimer's Disease
This research explores how a blood protein called fibrinogen interacts with a key Alzheimer's protein to affect brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11145101 on NIH RePORTER |
What this research studies
We are looking into how Alzheimer's disease and blood vessel problems are connected, which is still not fully understood. Our team has found that a protein central to Alzheimer's, called beta amyloid, can team up with fibrinogen, a protein involved in blood clotting. This combination can lead to abnormal blood clots and inflammation, potentially harming brain cells. We've also discovered that these beta amyloid-fibrinogen complexes can be toxic to brain cells even without forming clots. Understanding these interactions could open new doors for treatments.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of Alzheimer's disease and future treatment possibilities.
Not a fit: Patients seeking immediate treatment options or direct clinical trial participation may not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Alzheimer's disease by targeting the interaction between beta amyloid and fibrinogen.
How similar studies have performed: This work builds upon two decades of prior research showing connections between beta amyloid and fibrinogen in Alzheimer's disease.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Strickland, Sidney — Rockefeller University
- Study coordinator: Strickland, Sidney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.