Fermented foods, diet, and your gut-immune health
Impact of Diet on Intestinal Microbiota-Host Dynamics
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11169672
This project tests whether molecules in fermented vegetable brine, especially lactate, can change gut bacteria and immune responses in adults with type 2 diabetes or metabolic inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11169672 on ClinicalTrials.gov |
What this research studies
From a patient's point of view, researchers are focusing on molecules found in fermented vegetable brine to see how they change gut microbes and immune cells that matter for diabetes and allergy. The work combines lab experiments, animal studies, and samples from adult participants to trace how these molecules help new bacterial strains take hold and affect inflammation. Some parts involve controlled exposure to fermented foods or their components and regular collection of stool and blood for analysis. The goal is to map how diet-driven changes in the microbiome influence immune regulation and metabolic health.
Who could benefit from this research
Good fit: Adults age 21 and older with type 2 diabetes, obesity-related insulin resistance, or related gut inflammatory conditions who can provide stool and blood samples and follow dietary guidance would be ideal candidates.
Not a fit: People under 21, pregnant individuals, or patients whose conditions are unrelated to metabolic or gut inflammation are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this research could point to dietary or probiotic strategies that increase gut diversity and reduce inflammation in adults with type 2 diabetes.
How similar studies have performed: Early human and animal studies suggest fermented foods can boost microbiota diversity and lower inflammation, but the specific molecules and mechanisms in type 2 diabetes are still being clarified.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SONNENBURG, JUSTIN L — STANFORD UNIVERSITY
- Study coordinator: SONNENBURG, JUSTIN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus