Faulty DNA repair linked to lupus
Aberrant DNA Repair and Lupus
['FUNDING_OTHER'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11321160
This work looks at whether mistakes in genes that fix DNA help cause lupus, especially in people from groups that have higher rates of the disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11321160 on ClinicalTrials.gov |
What this research studies
Researchers are studying specific DNA-repair genes that they found more often in people with systemic lupus erythematosus (lupus). They put those human gene variants into mice to see whether the animals develop lupus-like immune changes and organ problems. The team also analyzes human genetic data and immune samples to connect the mouse findings back to people with lupus. The goal is to understand how these gene changes change immune tolerance and antibody production.
Who could benefit from this research
Good fit: People with systemic lupus erythematosus, especially those with a family history or those from ancestries with higher lupus prevalence (including African, Hispanic, Asian, and Native American backgrounds), are the most relevant to this research.
Not a fit: People without lupus or whose conditions are unrelated to immune system dysfunction are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could reveal biological causes of lupus and point to new targets for diagnostics or treatments.
How similar studies have performed: Prior mouse experiments by this group have produced lupus-like disease from DNA-repair gene changes, but translating those findings into human therapies is still early.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWEASY, JOANN B. — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: SWEASY, JOANN B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.