Fatty acid–binding proteins and how they control appetite
Molecular Drivers of FABP-mediated Endocannabinoid Signaling for Appetite Regulation
['FUNDING_OTHER'] · CITY COLLEGE OF NEW YORK · NIH-11385775
This project looks at how proteins that carry natural cannabinoids change hunger signals and body weight.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CITY COLLEGE OF NEW YORK (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11385775 on ClinicalTrials.gov |
What this research studies
This work studies small proteins called FABPs that shuttle natural endocannabinoids, which help regulate hunger and metabolism. Researchers will use lab-based biochemical tests and animal models to measure how these molecules bind, move, and are broken down at near-physiological levels. They will map binding sites and molecular changes to explain why some patterns lead to weight gain while others do not. Trainees at multiple career stages will participate in the experiments and analyses.
Who could benefit from this research
Good fit: Adults with overweight, obesity, or type 2 (adult-onset) diabetes interested in research on appetite and metabolic signals would be most relevant.
Not a fit: People without metabolic or weight concerns, children, or pregnant people would be unlikely to get direct benefit from this basic research.
Why it matters
Potential benefit: If successful, the findings could point to new drug targets or tests to help control appetite, reduce obesity, and improve diabetes care.
How similar studies have performed: Mouse studies have linked FABP and PPAR changes to obesity, but the detailed molecular transport and binding mechanisms in human-relevant conditions are largely untested.
Where this research is happening
NEW YORK, UNITED STATES
- CITY COLLEGE OF NEW YORK — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STARK, RUTH E. — CITY COLLEGE OF NEW YORK
- Study coordinator: STARK, RUTH E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus