Fat molecule patterns linked to high blood pressure in the lung arteries
Lipidomics of Pulmonary Vascular Disease
['FUNDING_R03'] · JOHNS HOPKINS UNIVERSITY · NIH-11261180
This project looks at blood fat patterns to find links with pulmonary arterial hypertension in people at risk, such as those with scleroderma.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11261180 on ClinicalTrials.gov |
What this research studies
You would be part of work that measures many different lipid (fat) molecules in blood using high-resolution lipidomics. Researchers will compare those lipid patterns with measurements of right heart and lung blood-vessel function and with clinical outcomes. The team will validate findings by checking them in large external patient groups and existing cohorts. The goal is to identify reproducible lipid signatures that point to biological pathways that might be changed by diet or drugs.
Who could benefit from this research
Good fit: Ideal candidates are people with pulmonary arterial hypertension or those at high risk (for example, people with scleroderma) who can provide blood samples and have heart and lung function data.
Not a fit: Patients seeking immediate treatment are unlikely to benefit directly because this is an observational biomarker validation effort rather than a therapy trial.
Why it matters
Potential benefit: If successful, this could reveal blood lipid markers that help predict or guide new dietary or drug approaches to prevent or treat pulmonary arterial hypertension.
How similar studies have performed: Previous studies have found lipid abnormalities in PAH and LCFAs before diagnosis in scleroderma, but comprehensive high-resolution lipidomic links to right-heart and pulmonary vascular function remain relatively new and need validation.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMPSON, CATHERINE — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SIMPSON, CATHERINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.