Faster Ways to Create Animal Models for Human Diseases
Rapid Generation of Transgenic Rhesus Macaques using a Safe-harbor Genomic Docking Site
['FUNDING_R21'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11124191
This work aims to develop quicker and more affordable methods to create specialized rhesus macaque models, helping scientists better understand and find treatments for human diseases.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11124191 on ClinicalTrials.gov |
What this research studies
Scientists are working to create nonhuman primate models with specific genetic changes to better understand human diseases. While current methods have led to the birth of healthy, genetically altered macaques, they are often too slow and costly for widespread use. This project plans to adapt a proven genetic technique, previously used in rodents, to make creating these advanced macaque models much faster and more efficient. By developing a 'docking site' in the macaque genome, researchers can more easily insert desired genetic material, which could speed up the creation of new models for many different conditions.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but it aims to benefit patients by improving the tools available for studying human diseases.
Not a fit: Patients will not receive direct medical benefit from this specific project, as it focuses on developing research tools rather than direct patient care.
Why it matters
Potential benefit: If successful, this work could accelerate the development of new animal models, leading to a deeper understanding of human diseases and potentially faster discovery of new treatments.
How similar studies have performed: Existing methods have already produced genetically altered nonhuman primates, and the proposed approach adapts a successful technology from rodent research.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BIMBER, BENJAMIN — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: BIMBER, BENJAMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.