Faster tests to measure proteins in individual breast cancer cells
Advanced Sample Preparation, Separation and Multiplexed Analysis for In-Depth Proteome Profiling of >1000 Single Cells Per Day
Developing faster lab methods to measure many proteins in single cancer cells so people with breast cancer can get more detailed tumor information for better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project ID | NIH-11145977 on NIH RePORTER |
What this research studies
This project will develop faster lab methods that let researchers measure thousands of proteins in individual cancer cells each day. They will use mass spectrometry plus improved sample processing and multiplexing with chemical tags to analyze many single cells quickly. The team aims to achieve throughput above 1,000 single cells per day while keeping deep protein coverage. Higher-speed profiling is intended to reveal rare or resistant tumor cell subgroups that bulk tests miss.
Who could benefit from this research
Good fit: People with breast cancer who are willing to donate tumor tissue or biopsy samples for laboratory analysis would be the most relevant participants.
Not a fit: People without cancer or those who do not provide tissue samples would not directly benefit from this laboratory-focused project.
Why it matters
Potential benefit: If successful, this could enable more precise tumor profiling that helps guide treatment choices and spot resistant cancer cell subpopulations earlier.
How similar studies have performed: Early single-cell proteomics studies have shown it's possible to measure thousands of proteins per cell, but scaling to thousands of cells per day is a new and active challenge.
Where this research is happening
Provo, United States
- Brigham Young University — Provo, United States (Active)
Researchers
- Principal investigator: Kelly, Ryan T — Brigham Young University
- Study coordinator: Kelly, Ryan T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.