Faster, safer gene editing in pigs for medicine and farming
Enhancing The Value of Pigs for Agriculture and Biomedical Applications By Using Novel Genome Editing Strategies
This project develops faster, safer ways to edit pig genes so researchers can create animal models that better mirror human diseases and help improve agricultural traits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11127528 on NIH RePORTER |
What this research studies
Researchers are improving CRISPR and related genome-editing methods to make genetically engineered pigs more reliable and quicker to produce. They will measure unintended DNA changes and optimize techniques to reduce those off-target effects. The team will use these improved methods to create pig models that reproduce human conditions such as cystic fibrosis and certain immune disorders. Faster, safer pig models aim to speed up the path from lab discoveries to therapies and agricultural improvements.
Who could benefit from this research
Good fit: Patients with conditions commonly modeled in pigs, such as cystic fibrosis or certain immune disorders, are the most likely to benefit from advances enabled by this research.
Not a fit: People seeking immediate treatments or direct enrollment in a clinical trial would not benefit directly because this is preclinical animal research.
Why it matters
Potential benefit: If successful, this work could speed development of new treatments by providing more accurate and readily available pig models of human diseases.
How similar studies have performed: Researchers have used CRISPR to create pig disease models before, but improving safety and reducing the time to generate models remains an active and necessary goal.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Lee, Kiho — University of Missouri-Columbia
- Study coordinator: Lee, Kiho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.