Fast single-cell protein test to help guide cancer treatment
Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology
['FUNDING_SBIR_2'] · APERTURE BIO, INC. · NIH-11247614
A company is developing a quick test that reads proteins in individual tumor and immune cells to help doctors pick better treatments for people with cancer.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | APERTURE BIO, INC. (nih funded) |
| Locations | 1 site (ALLSTON, UNITED STATES) |
| Trial ID | NIH-11247614 on ClinicalTrials.gov |
What this research studies
You could have a tiny biopsy or fragile sample analyzed one cell at a time to show which proteins are present in tumor and immune cells. The project is building a rapid lab platform and companion software that works on common immunofluorescent microscopes while preserving samples. Results would report protein expression, cell states, and immune–tumor co-localization using a validated immune-cell panel and computational reports. The approach is meant to work across different tumor types so it could help many people facing cancer.
Who could benefit from this research
Good fit: People with cancer who can provide a biopsy or other suitable tissue sample and whose care teams want detailed single-cell protein information would be the best candidates.
Not a fit: Patients without usable tissue samples, those with cancers not amenable to tissue-based testing, or patients for whom the test has not been validated may not benefit.
Why it matters
Potential benefit: If successful, this test could help personalize therapy choices by revealing which cells express drug targets and how immune cells are interacting with a tumor, potentially improving treatment success and avoiding ineffective therapies.
How similar studies have performed: Single-cell protein profiling is an emerging area with promising early research, but this specific rapid, microscope-compatible approach is relatively new and not yet widely adopted clinically.
Where this research is happening
ALLSTON, UNITED STATES
- APERTURE BIO, INC. — ALLSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETERSON, HANNAH MARIE — APERTURE BIO, INC.
- Study coordinator: PETERSON, HANNAH MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Patient