Fast, reliable tests for thinking, craving, and emotion in addiction

Utility of adaptive design optimization for developing rapid and reliable behavioral paradigms for substance use disorders

['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11121089

This project uses smart adaptive testing to create shorter, more accurate behavior tests for people with substance use problems.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorVIRGINIA COMMONWEALTH UNIVERSITY (nih funded)
Locations1 site (RICHMOND, UNITED STATES)
Trial IDNIH-11121089 on ClinicalTrials.gov

What this research studies

You would do brief computerized tasks that look at thinking and self-control, craving and reward, and negative emotions. A smart computer method (Bayesian adaptive design) picks the most informative questions and task trials for each person so testing can be much shorter. Researchers will compare the new short tests to standard longer batteries and check whether results stay consistent over time. The goal is to produce quick, reliable probes that could be used in clinics and research to better understand each person’s addiction profile.

Who could benefit from this research

Good fit: Adults with current or past substance use problems (for example alcohol or other drugs) who can complete brief computerized behavioral tasks would be the best fit.

Not a fit: People who cannot use computer-based tasks because of severe cognitive, visual, or motor impairments, or those seeking immediate treatment rather than testing, are unlikely to gain direct benefit from participating.

Why it matters

Potential benefit: If successful, clinicians and researchers could learn a person’s brain-behavior profile faster and more precisely, which could help tailor treatments and track progress.

How similar studies have performed: Adaptive testing methods have sped up and improved precision in other cognitive tasks, but applying Bayesian adaptive optimization specifically to addiction-related batteries is relatively new.

Where this research is happening

RICHMOND, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.