Fast, precise detection of kidney scarring with dual‑mode microscopy
Rapid quantitative renal fibrosis evaluation with dual-mode microscopy
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11322150
This project offers a fast, low‑cost microscope method to find and map kidney scarring on routine biopsy slides for people with suspected or known kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11322150 on ClinicalTrials.gov |
What this research studies
If you've had or might need a kidney biopsy, this work aims to read the standard H&E slides already made in pathology to spot and measure scar tissue (fibrosis) more quickly. Current methods often require extra stains, add cost, and can vary between labs, but the DUET dual‑mode microscope is designed to detect collagen and other macromolecules directly from H&E. The team plans to optimize the imaging and digital analysis (including algorithmic interpretation) and then deploy and test the system on clinical biopsy samples. The goal is rapid, reproducible digital reports of how much and where scarring is present.
Who could benefit from this research
Good fit: Ideal participants are people with suspected or confirmed kidney disease who have had or will have a kidney biopsy and whose biopsy slides can be reviewed or sent to the study team.
Not a fit: Patients without kidney disease, those who will not have a biopsy, or conditions where fibrosis is not relevant are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could give patients faster, cheaper, and more consistent information about kidney scarring to guide treatment decisions.
How similar studies have performed: Related imaging and AI approaches for detecting tissue scarring have shown promise, but applying this specific DUET dual‑mode method to routine H&E kidney biopsies is relatively new and still under clinical testing.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FEREIDOUNI, FARZAD — EMORY UNIVERSITY
- Study coordinator: FEREIDOUNI, FARZAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.