Family genetics linking autism and fragile X syndrome
A Family Genetic Study of Autism and Fragile X Syndrome
The team looks at whether changes in the FMR1 gene are linked to social language difficulties in people with autism, fragile X syndrome, and their family members.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11403972 on NIH RePORTER |
What this research studies
You and family members could take part in detailed language and social communication tests and brain-based measurements to look for patterns tied to genes. The team compares people with fragile X syndrome, carriers of the FMR1 premutation, individuals with autism, and first-degree relatives to find shared or distinct pragmatic language features. Researchers apply deep behavioral and neural phenotyping plus advanced computer/AI analyses to connect genetic variation to specific social-communication skills. Findings aim to clarify how FMR1-related biology contributes to everyday language and social challenges.
Who could benefit from this research
Good fit: Ideal candidates include individuals with fragile X syndrome, people who carry the FMR1 premutation (often family members), people with autism spectrum disorder, and their first-degree relatives, including children.
Not a fit: People without autism, fragile X, or family ties to someone with these conditions are unlikely to directly benefit from participating.
Why it matters
Potential benefit: If successful, this work could point to genetic and brain-based markers that support earlier diagnosis and more personalized communication supports for people with autism or fragile X.
How similar studies have performed: Previous work from this group found parallels in pragmatic language between the broad autism phenotype and FMR1 premutation carriers, while the combined deep behavioral, neural, and AI-driven approach is relatively novel.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Losh, Molly C — Northwestern University
- Study coordinator: Losh, Molly C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.