Family genes that protect memory and healthy aging
Core A Administrative
Researchers are searching for rare family genes that help members of long-lived families keep their memory sharp and age more healthily.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11096292 on NIH RePORTER |
What this research studies
This project follows families where many relatives live much longer than average and collects repeated health, memory, and lifestyle information across visits. Researchers use whole-genome sequencing and genetic analyses to find rare, family-specific gene changes linked to strong cognitive performance and resilience to dementia. Participants give blood and clinical measures so investigators can compare affected and protected families and trace protective patterns across generations. The goal is to point to biological pathways that could guide future prevention or treatments.
Who could benefit from this research
Good fit: Ideal candidates are adults who are members of families with exceptional longevity, including offspring and grandchildren already enrolled or eligible for the Long Life Family Study.
Not a fit: People seeking immediate symptom-relief or clinical treatment for Alzheimer's are unlikely to gain direct, short-term benefits from this genetic and observational research.
Why it matters
Potential benefit: If successful, this work could reveal genes or pathways that lead to new ways to prevent or treat memory loss and Alzheimer's-related conditions.
How similar studies have performed: Previous LLFS publications and other family-based genetics studies have identified rare protective variants for healthy aging and cognition, but turning those findings into treatments remains early.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Province, Michael a. — Washington University
- Study coordinator: Province, Michael a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.