Factors affecting survival in older adults with glioblastoma
Official title: Extratumoral biological determinants that decrease survival in older adults with glioblastoma
Funded at Loyola University Chicago · NIH-11080903 · Data updated 2026-11-12
This study is looking into why older adults, especially those over 65, have a harder time surviving glioblastoma, a tough brain tumor, and aims to find out how their bodies might respond differently to standard treatments so that doctors can create better care plans just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | August 19, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 5R01NS129835-03 |
| Project ID | NIH-11080903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with wild-type glioblastoma.
✕Less likely to help
Patients under the age of 65 or those with glioblastoma types other than wild-type may not benefit from this research.
What this research studies
This research investigates why older adults, particularly those aged 65 and above, have poorer survival rates when diagnosed with glioblastoma, a common and aggressive brain tumor. The study focuses on the biological determinants outside the tumor that may influence treatment outcomes, particularly in patients receiving standard therapies like radiation and temozolomide. By analyzing gene expression and other biological factors, the research aims to identify why older patients fare worse compared to younger individuals with the same condition. The findings could lead to improved treatment strategies tailored for older adults.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and improved survival rates for older adults diagnosed with glioblastoma.
How similar studies have gone: While there have been studies on glioblastoma, this research specifically targeting older adults and their unique biological responses is relatively novel.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Wainwright, Derek Alan — Loyola University Chicago
- Study coordinator: Wainwright, Derek Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.