Factors affecting survival in older adults with glioblastoma
Extratumoral biological determinants that decrease survival in older adults with glioblastoma
['FUNDING_R01'] · LOYOLA UNIVERSITY CHICAGO · NIH-11080903
This study is looking into why older adults, especially those over 65, have a harder time surviving glioblastoma, a tough brain tumor, and aims to find out how their bodies might respond differently to standard treatments so that doctors can create better care plans just for them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY CHICAGO (nih funded) |
| Locations | 1 site (MAYWOOD, UNITED STATES) |
| Trial ID | NIH-11080903 on ClinicalTrials.gov |
What this research studies
This research investigates why older adults, particularly those aged 65 and above, have poorer survival rates when diagnosed with glioblastoma, a common and aggressive brain tumor. The study focuses on the biological determinants outside the tumor that may influence treatment outcomes, particularly in patients receiving standard therapies like radiation and temozolomide. By analyzing gene expression and other biological factors, the research aims to identify why older patients fare worse compared to younger individuals with the same condition. The findings could lead to improved treatment strategies tailored for older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with wild-type glioblastoma.
Not a fit: Patients under the age of 65 or those with glioblastoma types other than wild-type may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and improved survival rates for older adults diagnosed with glioblastoma.
How similar studies have performed: While there have been studies on glioblastoma, this research specifically targeting older adults and their unique biological responses is relatively novel.
Where this research is happening
MAYWOOD, UNITED STATES
- LOYOLA UNIVERSITY CHICAGO — MAYWOOD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WAINWRIGHT, DEREK ALAN — LOYOLA UNIVERSITY CHICAGO
- Study coordinator: WAINWRIGHT, DEREK ALAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.