Factors affecting outcomes in Veterans with low-risk prostate cancer
Official title: Multi-level factors impacting clinical outcomes in Veterans with low-/intermediate-risk prostate cancer
Funded at VA Greater Los Angeles Healthcare System · NIH-11052413 · Data updated 2026-11-12
This study is looking at how different factors, like your background and health environment, can affect the outcomes for Veterans with low- to intermediate-risk prostate cancer, and it aims to create a helpful tool to identify those who might be at greater risk of their cancer spreading, so they can get more personalized treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01CX002710-01A2 |
| Project ID | NIH-11052413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans diagnosed with low- to intermediate-risk prostate cancer, particularly those considering active surveillance.
✕Less likely to help
Patients with high-risk prostate cancer or those who have already undergone aggressive treatment may not benefit from this research.
What this research studies
This research investigates the various factors that influence the clinical outcomes of Veterans diagnosed with low- to intermediate-risk prostate cancer. It focuses on understanding how ancestry, genetic variants, social determinants of health, and environmental exposures may contribute to the risk of metastatic progression in these patients. By analyzing a large cohort of Veterans receiving care within the VA Healthcare System, the study aims to develop a prognostic tool that can help identify patients at higher risk for metastasis. This tool could guide treatment decisions, allowing for more personalized care.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and tailored treatment strategies for Veterans with low-risk prostate cancer.
How similar studies have gone: Previous research has shown promise in using multi-level factors to predict cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
VA Greater Los Angeles Healthcare System
Los Angeles, United States Active
Researchers
- Principal investigator: Garraway, Isla Pearl — VA Greater Los Angeles Healthcare System
- Study coordinator: Garraway, Isla Pearl
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.