EZH2-PRC2 Regulation and blood cancer biology
Official title: Regulation of Hematopoiesis by the EZH2-PRC2 Complex
Funded at University of Nevada Las Vegas · NIH-11376485 · Data updated 2026-11-12
A study at UNLV will explore how EZH2, a protein that silences genes, affects blood stem cells and may drive blood cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project start | July 21, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $149,582 |
| NIH project number | 5R16GM159134-02 |
| Project ID | NIH-11376485 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients with blood cancers or pre-cancerous blood disorders where EZH2-related pathways are implicated (through future translational research).
✕Less likely to help
Patients without EZH2-related disease or participation in any future clinical translation may not benefit directly.
What this research studies
Researchers will use a mouse model with a specific EZH2 change (K20R) to see how resistance to a natural regulatory process alters blood stem cell growth and bone marrow function. They will combine gene editing, cellular analyses, and mouse experiments to understand how EZH2 stability and degradation influence cancer development. The goal is to identify where and how EZH2 drives disease so future therapies can target these pathways. This work centers on mechanisms that could impact patients with blood cancers and related disorders.
Why it matters
Potential benefit: If successful, this research could uncover new targets to treat or prevent blood cancers linked to EZH2 dysregulation.
How similar studies have gone: Previous work shows EZH2 methylation regulates protein stability and influences cancer-related pathways, supporting the potential for impact.
Where this research is happening
-
University of Nevada Las Vegas
Las Vegas, United States Active
Researchers
- Principal investigator: Sun, Hong — University of Nevada Las Vegas
- Study coordinator: Sun, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.