Extra gene copies on chromosome 1q that help melanoma spread
Chromosome 1q ceRNAs in Melanoma Progression and Metastasis
This work looks at how extra copies of certain genes on chromosome 1q let melanoma cells grow and spread, which could help people with melanoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11212185 on NIH RePORTER |
What this research studies
You would be helping researchers who are studying how gains of chromosome 1q—found in many melanomas—lead to higher levels of certain RNAs that act like 'sponges' for tumor-suppressing microRNAs. The team will focus on genes such as CEP170, NUCKS1, and ZC3H11A and test their effects in lab-grown melanoma cells and in animal models. They will also analyze tumor DNA and RNA to see how common these 1q copy number gains are in patients and whether they link to metastasis. If blocking these RNA interactions slows cancer spread in models, the findings could point to new targets for future therapies or tests.
Who could benefit from this research
Good fit: People with melanoma—especially those with advanced or metastatic tumors or tumors that show extra copies of chromosome 1q—would be most relevant for participation.
Not a fit: People without melanoma or with early-stage melanoma that lacks 1q copy number gains may not directly benefit from this work.
Why it matters
Potential benefit: If successful, this research could identify new targets to stop or slow melanoma metastasis and guide development of future treatments.
How similar studies have performed: Previous studies have shown that ceRNA interactions and microRNA 'sponging' can promote cancer, but applying this idea specifically to 1q gains in melanoma is a newer, developing area.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Karreth, Florian — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Karreth, Florian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.